Did you know ?

Biospace Lab’s digital autoradiography systems presents significant interests to complement in vivo acquisitions with

Indeed, autoradiography acquisitions only require the preparation of tissue
sections since the imagers will detect
the exact same labelling which have been used for the SPECT or PET acquisition.

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The BetaIMAGER™ systems from Biospace Lab are unique solutions for rapid, high resolution, quantitative autoradiography of Beta emitting radioisotopes. Both systems need only a few hours to acquire data that may require exposures of many days or several weeks using autoradiography film or Storage Phosphor Screens.

Disintegrations are detected in real-time and the data display is continuously updated during acquisition, so that under or over exposure of the sample, a common problem for either film or Storage Phosphor Screens, are both avoided. The linearity of response extends over four orders of magnitude (1:10,000) and advanced image analysis software tools are provided for accurate quantification and analysis of data.

BetaIMAGER™ systems detect all commonly used beta emitting radioisotopes (3H, 14C,32P, 35S, 125I) and positron emitting (PET) isotopes directly. They also detect the secondary beta emissions from several gamma emitting radioisotopes (123I, 131I, 99mTc,201Tl, 111In).

The sensitivity and resolution obtained with the ultra low energy beta emitting isotope tritium is exceptional and unequalled by any other technology.

BetaIMAGER™ systems can simultaneously acquire data from multiple radioisotopes; whilst accurately discriminating between the separate emissions based on either a difference in emission energy or radioactive half-life. The multiplexing of various ligands and tracers in a single experiment is thereby made possible.

Choose the system adapted to your needs

Whatever the autoradiography application - either high speed or high resolution autoradiography- Biospace Lab has the ideal solution.

The BetaIMAGER TRACER turns autoradiography into a fast and easy routine

The BetaIMAGER™ TRACER system is the system of choice for applications requiring the highest sensitivity and either high throughput, or larger sample sizes; Exceptional sensitivity can be obtained even with ultra-low energy tritium emissions: the TRACER system detects tritium levels as low as 0,007 cpm/mm2


Read more about the TRACER system

The BetaIMAGER DFINE: the high resolution autoradiography solution


The BetaIMAGER™ DFINE system is the system of choice for applications involving smaller tissue sections and where the best possible spatial resolution is required,. Four samples, up to 24 x 32mm each in size can be loaded onto the automated stage for sequential image acquisition. Spatial resolution as high as 15μm can be achieved with Tritium.

Read more about the DFINE system

Real-time digital autoradiography

X-ray film or Storage Phosphor screen based autoradiography requires a two step blind acquisition process: expose and then scan

The exclusive real-time detection technology used in both systems is covered by World wide patent and makes it possible to display and accumulate counts in real-time:

Real-time autoradiogrpahy: distribution of D1 receptors in rat brain striatum following tritiated ligand binding

Key benefits:

- See data accumulating in real-time

- See the first results in minutes

- Avoid any under or over exposure of the sample

High sensitivity and rapid image acquisition

X-Ray film and Storage Phosphor screens are relatively insensitive to low energy isotopes such as tritium. The BetaIMAGER™ systems count all emitted particles, regardless of their energy. This direct beta counting technology of the BetaIMAGER systems provides unequalled performance: the BetaIMAGER™ tRACER system is some 500X more sensitive and the BetaIMAGER™ dFINE system some 50X more sensitive to tritium than either X-ray film or Storage Phosphor Screen. The BetaIMAGER™ tRACER system is unique in its ability to detect tritium levels as low as 0.007 cpm/mm2

Key benefits:

- Unmatched sensitivity cuts your data acquisition form weeks to hours

- Detect ultra-low levels of bound radiolabeled ligands

Use minimal amounts of radiolabeled compounds

Reduce radioactive waste

Minimize experimental costs

- Reduce the number of experiments thanks to the reproducibility of the system.

Accurate quantification

The BetaIMAGER systems provide precise localization and quantification of beta emitting redioligands. The advanced image analysis tools of the M3 vision sofware allow for direct analysis of digital data and a better than 1:10,000 linear dynamic range ensures accurate quantification over the widest possible range.

Linear dynamic range of the BetaIMAGER

Courtesy of Dr Alain Schweizer, Novartis

Key benefit:

Detect and quantify both high and low sample concentrations in a single data acquisition

Patented technology for the simultaneous detection and discrimination of multiple radioisotopes

A single sample can be simultaneously labeled with several radioisotopes and the specific contribution from each detected during a single data acquisition. Discrimination can be based on emission energy (2 radioisotopes), or on radioactive half life (2 isotopes or more). Examples of dual-detection radioisotope pairs include 3H/14C,3H/35S, 3H/32P or 33P and an example of a multi-label combination would be 99mTc/ 111In/18F

This unique radioisotope discrimination feature allows the development of more rapid and accurate protocols for recording the distribution of several molecules simultaneously in a single specimen:

- Co-localization of different receptors, or receptors and ligands

- Mapping complex functional activity with pathology

- Comparing specific gene expression with a reference gene




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