Did you know ?

Biospace Lab’s digital autoradiography systems presents significant interests to complement in vivo acquisitions with

Indeed, autoradiography acquisitions only require the preparation of tissue
sections since the imagers will detect
the exact same labelling which have been used for the SPECT or PET acquisition.

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PhotonIMAGER™ systems
Dynamic Optical Imaging Systems for Fluorescence and Luminescence

The Photon Imagers are dynamic, modular systems for the non-invasive detection, localization and quantification of dynamic optical signal - bioluminescence or fluorescence from live animals. A unique photon counting technology makes it extremely sensitive from the very start of image acquisition and enables the unparalleled kinetic recording of dynamic processes without the need for setting acquisition time, or pixel binning prior to imaging. The PhotonIMAGER™ continuously displays the light distribution during an experiment and image acquisition can be stopped at any time. This is a key advantage for luminescence imaging and can open new horizons for fluorescence imaging. Unlike other pre-clinical Imaging systems, the real-time imaging capability of the PhotonIMAGER™ delivers impressive performance, whilst its modular design ensures that the systems capabilities can be extended, as further state-of-the-art imaging technologies become available.

Key Benefits of the PhotonIMAGER™ systems:

Easy Bioluminescence & Fluorescence Imaging
Unmatched Performance & accuracy
Real-time imaging capability
Modular philosophy
Ease of use

Easy Luminescence & Fluorescence Imaging

- Full spectrum imaging capability from blue to near-infrared in luminescence and fluorescence:
Continuous selection of excitation wavelength from 400 up to 800 nm

- Equipped with up to 14 band pass emission filters (455nm to 815nm) and one high pass filter (810LP)

- Automated autofluorescence substraction

- Spectral Unmixing

- Multilabeling Capacities

- From whole body to cell dimensions thanks to the Marcolens Addon Module.

High Sensitivity with an Intensified CCD camera

The PhotonIMAGER™design incorporates an intensified CCD camera, which makes it highly sensitive from the very first moments of image acquisition. iCCD technology amplifies all light emitted from the specimen by a factor 10^6; making the Photon Imager systems some of the most sensitive on the market for detection of low signal levels. Read more about the operating principles

- Detection of weak signals
- Negligible read out noise
- No more pixel binning and exposure time settings prior to imaging
- Acquisition from the very first second
- High Temporal Resolution of 23ms

Accurate signal localisation and quantification

Outstanding dynamic range
The PhotonIMAGER™ design ensures signal intensification by a factor of 10^6 and as a consequence, the PhotonIMAGER™ systems are some of the most sensitive systems on the market for detection of weak light signals. Furthermore, users of the PhotonIMAGER™ systems can rely on an unequalled linear dynamic range: bioluminescence expression in tissues can thereby be followed, quantified and compared; from early detection of weak signal, through to later development of higher signal strength.

4-View and 3D imaging
The 4-View module helps increasing the analysis accuracy and relevance of your acquisitions. It offers a precise quantification by providing you not only one but several views of your animal (dorsal, ventral, and lateral views) simultaneously and in real time. The 4-View module is an excellent tool for a better localization of optical signals. Read more

With the 3D Pack installed, the PhotonIMAGER™ retains its real-time imaging capability; making dynamic 3-dimensional bioluminescence signal measurement over time (4D Imaging) a reality. Read more

Dynamic imaging capability

Thanks to its high temporal resolution and excellent sensitivity the PhotonIMAGER™continuously displays the light distribution from the first seconds of the experiment and can be stopped at any time. The dynamic imaging capability of the PhotonIMAGER™ system allows the signal kinetics to be followed precisely and independently, even when the signal is weak. It provides precise control over the time-zone selected for the measurement of each ROI, both during and following signal acquisition. The ideal signal measurement window can always be accurately selected for each animal or anatomical region in turn

- Visualize results in seconds
- Follow your acquisition in real-time and stop acquisition at any time
- No more guessing: Acquisition time or pixel binning settings prior to imaging is not necessary. - - Bias linked to bioluminescent reaction kinetics are suppressed
- No need to assume a hypothethical output curve as the actual kinetic curves are availabe
- Allows the recording of fast signal kinetics

Read more about the dynamic imaging capability

A modular system for all applications -
build your own system adapted to your research

The modular philosophy of the PhotonIMAGER™ systems allows you to keep up with the latest developments in imaging technologies existing optional modules and future options can be added to the basic instrument configuration.
Optical imaging has never been easier: change modules quickly, chose your module and acquisition mode on the touchscreen and start acquisition

Macrolens module
for high resolution optical imaging
In Actio module for imaging of freely moving animals
4-View - 3D module for an even better localization and quantification of optical signals
X-Ray module for a better anatomical localization of optical signals

Ease of use

- High throughput system for longitudinal studies up to 5 mice at the same time
- Ease of manipulation - sliding stage, continuously variable field of view
- Designed for maintenance of animal welfare - thermoregulated stage, anaesthesia system
- Multiple imaging modalities and comprehensive analysis by the M3Vision™ Software














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