Did you know ?

Biospace Lab’s digital autoradiography systems presents significant interests to complement in vivo acquisitions with
SPECT or PET.

Indeed, autoradiography acquisitions only require the preparation of tissue
sections since the imagers will detect
the exact same labelling which have been used for the SPECT or PET acquisition.

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APPLICATION NOTES- BetaIMAGER™ systems


Comprehensive functional imaging of metabolism, perfusion and interstitial fluid on histopathologic slices of infarcted myocardium.


Simultaneous imaging of distribution and quantification of three different radiolabeled markers in histopathologic slices of infarcted myocardium

Simultaneous observation of 3 different processes: metabolism, perfusion and interstitial fluid in organ of interest.

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Ex Vivo control of visual stimuli in rat brains by 18FDG imaging: a comparison of available techniques for tissue section imaging

Real-time particle counting digital instruments, i.e. the BetaIMAGER™ DFINE and the BetaIMAGER™ TRACER, are shown to be better suited for ex vivo imaging of ß+-labeled molecules than are phosphor screens. Their good spatial resolution, particularly that of the DFINE, allows excellent visualization of small areas of interest in the brain or other organs. Further, real-time acquisition and visualization allow rapid assessment of the experiment and avoid over- and under-exposure, as is often the case with film when activity levels are not known.

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Simultaneous dual-isotope imaging of Technetium-99m and Thallum-201using the BetaIMAGER dFine system.


The objective of this study was to evaluate the potential of the time information recorded by the BetaIMAGERTM DFINE to resolve simultaneous dual-isotope imaging of a 99mTc-labeled perfusion tracer (99mTcN NOET) and of 201Tl in rat myocardium.

Quantitative comparison of uptake of a 2 given radiolabeled flow tracers in myocardial slices

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Validation of amyloid-beta plaque formation in Alzheimer disease PET studies by high resolution digital autoradiography using the BetaIMAGER dFine


The BetaIMAGER DFine was used in conjunction with various Ex vivo/in vitro techniques, to cross-validate PET Imaging data showing amyloid β (Aβ) plaque formation in the APP/PS1 transgenic mouse model of Alzheimer’s disease (AD). High resolution digital autoradiography images of the highly specific Aβ radioligand [11C]6-OH-BTA-1 ([11C]PiB) correlated with fluorescence microscopy Data. Topographical PET data showing extra-cerebral localization of [11C]PiB was validated by autoradiography. Dual labeling showed accumulation of both [11C] and [3H]PiB in Ab40/Ab42 positive plaques at early stages of the disease

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