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Biospace Lab’s digital autoradiography systems presents significant interests to complement in vivo acquisitions with

Indeed, autoradiography acquisitions only require the preparation of tissue
sections since the imagers will detect
the exact same labelling which have been used for the SPECT or PET acquisition.

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PhotonIMAGER systems

Cerenkov Luminescence imaging on the PhotonIMAGER™ system -
biodistribution of the beta emitting radiotracer 32P

Cerenkov imaging is shown to be a valid tool for complementing more commonly used BLI, FLI, SPECT and PET imaging modalities. This study successfully demonstrated how visualization of tumor onset/progression can be achieved by detecting Cerenkov luminescence from injected 32P radiolabel. The PhotonIMAGER™ system is shown to be perfectly adapted to monitor Cerenkov Luminescence in vivo.
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Macrolens Module: detecting metastasis in mouse lung

It has been demonstrated in this study that it is possible to resolve metastasis in the lung ex vivo at higher magnification, even when they cannot be resolved in vivo during whole body imaging.

The Macrolens module also allows precise localization of closely spaced signals making it possible to reliably quantify each one.
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Real -Time monitoring of luminescent nanoprobe biodistribution

The biodistribution of luminescent nanoparticles can be controlled by altering their chemical surface and electrical charge. They can then be monitored in Real-Time using the PhotonIMAGER. This is of particular interest for pharmacological applications.
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In Actio Module: Real-Time luminescence imaging in freely moving small animals

This study demonstrates the performance of a device developed for whole body imaging of small moving animals at high time resolution. The system comprises a camera for photon counting of bioluminescence signal and a video monitoring function to track the animals movements. The In Actio Module allows Bioluminescence imaging where anesthetics are suspected to cause physiological interference, such as studies monitoring tumor growth.
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