Did you know ?

General anestheticscan introduce bias by disturbing the physiology and affecting signal expression, so affecting directly the pathology of an animal model.

With the In Actio Module of the PhotonIMAGER, you can avoid these side effects and improve your results

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OPTICAL IMAGING FOR NEUROSCIENCES

The central nervous system is challenging to image. Imaging the brain, for example, requires to detect signals through the skull of the animal when craniotomy is not an option. Bioluminescence may also differ due to the brain blood barrier, which can slow down the distribution of luciferin in tissue. You can find several examples of such acquisitions performed with the PhotonIMAGER™
       

Monitoring of brain cancer therapy
Tracking of stem cell migration
Ca2+ Imaging

Imaging of freely moving animals without anesthesia

               



Adeno associated virus (AAV) transfection 2 weeks incubation for viruses to infect neurons and mCherry to be expressed. Acquisition in vivo and excision of the brain 4View acquisition. Fluorescence Mode, 4-View Module

Courtesy of Dr Urade and Lazarus; OBI, Osaka, Japan

       

A transgenic Drosophila fly was imaged at high resolution using the Macrolens Module after administration of nicotine, which induces formation of a calcium wave in the fly brain. (Mag: 20x; FOV: 0.9 mm) (A) Different areas of the brain are activated sequentially. (B) Time profile analysis of the different areas during the calcium wave. (C) Movie of nicotine induced calcium response in the Drosophila mushroom bodies
           

Courtesy of Dr. J.R. Martin, Cellular and molecular neurobiology departement, Alfred Fressard Neurobiology Institute, CNRS, Gif sur Yvette, France

       

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