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Publication Alert : Keele University - Acta Biomaterialia

Defining a turnover index for the correlation of biomaterial degradation and cell basedextracellular matrix synthesis using fluorescent tagging techniques



Non-destructive protocols which can define a biomaterial’s degradation and its associated ability to support proliferation and/or promote extracellular matrix deposition will be an essential in vitro tool. In this study we investigate fluorescently tagged biomaterials, with varying rates of degradation and their ability to support cell proliferation and osteogenic differentiation. Changes in fluorescence of the biomaterials and the release of fluorescent soluble by-products were confirmed as accurate methods to quantify degradation. It was demonstrated that increasing rates of the selected biomaterials’ degradation led to a decrease in cell proliferation and concurrently an increase in osteogenic matrix production. A novel turnover index (TI), which directly describes the effect of degradation of a biomaterial on cell behavior, was calculated. Lower TIs for proliferation and high TIs for osteogenic marker production were observed on faster degrading biomaterials, indicating that these biomaterials supported an upregulation of osteogenic markers. This TI was further validated using an ex vivo chick femur model, where the faster degrading biomaterial, fibrin, led to an increased TI for mineralization within an epiphyseal defect. This in vitro tool, TI, for monitoring the effect ofbiomaterial degradation on extracellular matrix production may well act as predictor of the selected biomaterials’ performance during in vivo studies.




Katie Bardsley, Ian Wimpenny, Roni Wechsel, Yonatan Shachaf, Ying Yang, Alicia J.El Haj

http://dx.doi.org/10.1016/j.actbio.2016.09.002






New poster of Sanofi Pasteur for AFSTAL congress in Nantes


The PhotonIMAGER system to follow bacterial infections in mice in a non-invasive manner

This Sanofi Pasteur (Marcy-l’Étoile, France) study describes two new mouse models to follow the kinetics of infection with Pseudomonas aeruginosa and Staphylococcus aureus in longitudinal studies. Thanks to the Photon IMAGERTM system daily evaluation of the bacterial load was possible in vivo. Using a luciferase reporter gene expressed in both bacterial strains, direct correlation between CFUs and light emission could be assessed non-invasively and without any need for euthanasia or organ excision.

Focusing on the 3Rs principles, Sanofi Pasteur will be aiming to apply these models to current and future infectiology studies.


 




 

Dowload the poster

Implementation of murine infectious models using in vivo optical imaging

Kevin THIBAULT-DUPREY , Thierry DECELLE, Christophe CHARNAY, Lucie ENGELHART, Vladimir PERKOV
Sanofi Pasteur, Protection et Sciences de l’Animal, Marcy-l’Étoile, France

 

 

 

 

 

New publication from Fac de Pharma in Nature Materials

The PhotonIMAGER system for in vivo Imaging of  near-infrared persistent luminescence nanoparticles

A new study of our collaborators introduce a new generation of in vivo activated optical nanoprobes based on chromium-doped zinc gallete (ZGO). In this study Biospace Lab’s PhotonIMAGER system was used for real-timme in vivo Imaging of biodistribution of ZGO nanoparticles and persistent luminescence imainging of a tumour-bearing mouse
 

 

 

       In vivo comparision of widely known QDs and ZGO nanoparticles  

Bioluminescent and fluorescent images are from 5-week old female BALB/c mice after intramuscular and systemic injection of  50 μg of either 705nm  emitting carboxyl-QDs  or ZGO nanoparticles. Shown is highly sensitive     detection of the ZGO particles in deep tissues and complete lack of autofluorescence as compared to QDs (target to background ration 186 for ZGO and 16,7 for QDs)


 

 

Take a look on the whole study of our collaborators

The in vivo activation of persistent nanophosphors for optical imaging of vascularization, tumours and grafted cells

Thomas Maldiney1, Aurélie Bessière2, Johanne Seguin1, Eliott Teston1, Suchinder K. Sharma2, Bruno Viana2, Adrie J. J. Bos3, Pieter Dorenbos3, Michel Bessodes1, Didier Gourier2, Daniel Scherman1 and Cyrille Richard1


 

 

 

 

 

A new step in Biospace Lab’s history

Biospace is pleased to announce that it is now part of the Ateliers Laumonier group

The Ateliers LAUMONIER group is a French company founded in 1923 and specializes in the development of precision tools & equipment for the Hi Tech Industry (Aerospace, nuclear power, medical equipment…)

 

This is an exciting new step for Biospace Lab, which will not only greatly benefit from over 90 years of experience in engineering and manufacturing, but also from Ateliers Laumonier’s activities in the medical and biomedical industry via their LIMMED branch.

 

Biospace Lab is also delighted to announce the launch of its new TomoFluo™ module, for the PhotonIMAGER OPTIMA system, which will be unveiled on September 17th at the WMIC 2014 in Seoul, Korea. The TomoFLuo™ module is the first module developed in partnership with The LAUMONIER group, and is designed to achieve unrivalled sensitivity & accuracy in 3D Fluorescence imaging in vivo.

New publication from UCL-CABI

The PhotonIMAGER system to image bioluminescent SHOC2 knockdown tumors in mice
A new study of our collaborators discuss an attractive target of therapeutic intervention for pharmacological inhibition of ERK pathway - the MRAS-SHOC2-PP1 holoenzyme. As a part of the study Biospace Lab’s PhotonIMAGER system were used to image bioluminescent SHOC2 knockdown tumors in mice (MDA-MB-231-EcoR-Luciferase cells infected with shRNA lentiviruses)


SHOC2 knockdown inhibits tumor formation. Bioluminescent images are from the twelfth day of mice injected with the indicated MDA-MB-231 cells. Shown is the relative bioluminescent signal of the SHOC2 knockdown tumors compared to the control tumors (shSCRAM) in the same animal. Data represent the mean± SEM of at least four tumors (∗p< 0.005).


Take a look at the whole study of our collaborators:
AnMRAS, SHOC2, and SCRIB Complex Coordinates ERK Pathway Activation with Polarity and Tumorigenic Growth
UCL Cancer Institute, University College London, London WC1E 6BT, UK.



New edition of the PhotonIMAGER Optima


The New Edition of the PhotonIMAGER Optima system
For a better performance and ease of use in optical imaging

Here at Biospace Lab our aim is to always develop our systems by listening to market trends and most importantly the needs of our present and future customers. We designed the new edition of our PhotonIMAGER Optima system with this philosophy always in mind.

Discover the latest improvements:


The StereoCT Module


The StereoCT Module is a smart way to easily add anatomical context to your optical imaging studies without using complex and high-cost fully tomographic systems. The module makes it possible to approximate 3D organ anatomy using only two 2D X-Ray projections.

Download our article about the advantages and technology of StereoCT Imaging and the AtlasCo-registration Tool.


Airtight Imaging Box for High-Throughput studies


More and more researchers look for high-throughput methods for rapid and cost-effective preclinical imaging studies. With that in mind, we developed a new imaging box, where up to 14 mice can be imaged under gaseous anesthesia at the same time! The box has been developed in collaboration with Minerve.

- Heated
- Movable
- X-Ray and StereoCT compatible

The PhotonIMAGER Optima is the only system with 14 nosecone positions for optical imaging acquisitions!


The new 4-View Module

The4-View Module is an excellent tool for a better localization of optical signals as it allows simultaneous acquisition of the 4 sides of the animal.

The new design offers better performance and a heated anti-reflective bed for better animal care and reproducibility

- Improved fluorescence excitation
- X-Ray compatible
- Transillumination ready
- StereoCT ready


Learn more about the 4-View Module




Integrated X-Ray Flat Panel

The new flat panel now makes it possible to image 4 mice at the same time in X-Ray mode

New Optical Fiber

It offers better contrast in fluorescence and reduction of autofluorescence and provides better transmission for Infrared and Near infrared imaging.

Motorized Objective Holder Ring

No more manual handling of the objectives, the objective change is controlled in the acquisition sofware automatically.


 

 

 

 



Optical signals in 3D anatomical context

Did you know that now it is possible to analyze optical signals in an anatomical context without tomographic acquisitions? Find out how from our latest article and learn more about our development, the StereoCT Module, designed for the PhotonIMAGER™ in vivo optical imaging system.

· Digital Anatomical Atlas co-registration using two X-Ray projections

· Approximation of 3D organ anatomy

· Provides automatic quantification of signal for each organ

· Improves the localization and automatic quantification of the 3D optical signal

· Low dose (<500μGy) and fast (10-15 second acquisition; only seconds for reconstruction)

Download the article

New! StereoCT module for the PhotonIMAGER Optima

STEREOSCOPIC COMPUTER TOMOGRAPHY
The new solution for co-registration of optical signal
and accurate anatomical information


- Low dose
- Fast
- Easy overlay of optical data (fluorescence, bioluminescence and Cerenkov luminescence)
- Integrated anatomical atlas
- High-throughput (2 to 5 mice)

Learn more                


Image courtesy of B. Rousseau,
Victor Segalen Bordeaux II University, France
Latest Newsletter, June

Tumor targeting is of high clinical and biological relevance, and developing molecular imaging technologies for the visualization of tumors is extremely im-portant in cancer research. Optical imaging is a very promising technology for non-invasive high throughput tumor detection and tumor burden imaging thanks to some unique properties that no other method can provide. Optical imaging is highly costeffective, rapid, easy to use and can be readily applied to studying disease processes and biology in vivo. It is suitable for imaging across wide spatial scales; ranging from cells to organ systems and it is this property which makes it a sui-table approach for cancer research studies. Here, we’ll describe some methods to overcome challenges in cancer imaging using examples. Biospace Lab would like to present to you a world of opportunities in cancer research thanks to our new generation of modular optical imagers.

 

More accurate localization and quantification of tumor mass volumes- 3D imaging of tumors
Detection of small tumors- Integrated system for In vivo microscopy
Optical imaging without anesthesia
Tumor detection in deeper tissues- Near Infrared tumor imaging

Download the pdf

MARCH 6th, 2012

Biospace Lab S.A. and the Centre for Advanced Biomedical Imaging at University College London will collaborate on the development of novel real-time in vivo optical imaging applications and further development of the Biospace Lab PhotonIMAGER™ Optima pre-clinical imaging platform. The collaboration will bring together UCL experts in imaging, Dr Mark Lythgoe, and molecular probes, Dr Martin Pule, together with expertise from Biospace Lab S.A. to develop novel Molecular Imaging technologies for biomedical research applications. The initial focus will be on further method development in luminescence imaging and the integration of in vivo optical imaging with other in vivo imaging modalities, but it is hoped that the 3 year collaboration will additionally support a range of Biomedical research projects at UCL


Read the press release

DECEMBER 15th, 2011

Latest advances in multi-model imaging

Multimodality is becoming more and more important in Molecular Imaging, because the synthesis of the various data provided by several different imaging modalities can provide more reliable answers, based upon the complementary nature of the data available.


 

  • Multimodal Molecular Imaging—improved reliability of results
    Learn more about Cerenkov Luminescence Imaging
    Advantages of Cere-kov luminescence for pre-clinical optical imaging
    Developing a rapid,low dose X-Ray tomographic module for longitudinal studies
Download the newsletter
DECEMBER 6th, 2011

Biospace Lab and the ImaBio Group (IPHC, Strasbourg) are pleased to announce they are collaborating on the development of a new X-ray tomographic imaging module for use with the Biospace Lab PhotonIMAGER™ OPTIMA system, a fully modular and versatile preclinical optical imager developed for real-time in vivo luminescence or fluorescence studies. The new add-in module will be faster than current Micro CT systems and will provide more information on organs and tissues, while delivering a low radiation dose compatible with longtitudinal animal studies. Co-registration of anatomical data with optical data will help increase the reliability and accuracy of the functional data acquired.


Read the press release
SEPTEMBER 14th, 2011

Strasbourg: ImaBio groupe welcomes Biospace lab for the demonstration of a high performance optical imaging system, The PhotonIMAGER. Take a look at the article (in french) published in "La Gazette du Laboratoire"
AUGUST 1st, 2011

The new PhotonIMAGER brochure is available.You can download it here
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