PUBLICATION ALERT : ICAN, Paris - DIABETHES, 2018
The ceramide transporter CERT is involved in muscle insulin signaling defects under lipotoxic conditions.
In this scientific report, the authors investigated the importance of CERT in lipid induced insulin resitance .
Amongst other experiments, the researchers used digital autoradiography to study the effect of C2C12 myotubes treatment with the CERT inhibitor HPA12 on [3H]-Sphingosine conversion to [3H]-ceramide, [3H]-Sphingomyosine and [3H]-GlcCer.
C2C12 lipid extracts resolved by High performance Liquid chromatography were quantified by direct analysis of the HTPLC plates on the BetaIMAGER Tracer.
The results showed that most of the [3H]-sphingosine down-products were associated with ceramide and that CERT inhibition with HPA12 or palmitate treatment substantially reduced sphingomyelin (SM) production and no effect on Ceramide or GlcCer biosynthesis.
Cécile L. Bandet, Rana Mahfouz, Julien Véret, Athanassia Sotiropoulos, Maxime Poirier, Paola Giussani, Mélanie Campana, Erwann Philippe, Agnieszka Blachnio-Zabielska, Raphaëlle Ballaire, Xavier Le Liepvre, Olivier Bourron, Dušan Berkeš, Jan Górski, Pascal Ferré, Hervé Le Stunff, Fabienne Foufelle and Eric Hajduch*
PUBLICATION ALERT : UNICAEN, INSERM UMR-S U1237 - Theranostics 2018
Anesthesia Inhibits the Activity of the "Glymphatic System”
In this report, the researchers from Caen University Hospital (CHU Caen) took advantage of the PhotonIMAGER RT’s intensified CCD, which can : " dramatically increase the signal to noise ratio of NIRF signals" thanks to its fluorescence photocounting mode. NIRF acquisition times could be reduced to 22 ms, allowing
Using this functionality to investigate CSF circulation amid the glymphatic system hypothesis, the authors could observe a substancial increase in Indocyaning Green diffusion to the forebrain of non-anesthetized mice whilst the marker remained located in the cisterna magna of anesthetised animals. This findings, confirmed by MRI and ex vivo fluorometry analysis, strongly suggest that parenchymal CSF circulation is mainly active during wakefulness and significantly impaired during general anesthesia.
Clement Gakuba, Thomas Gaberel, Suzanne Goursaud, Jennifer Bourges, Camille Di Palma, Aurélien Quenault, Sara Martinez de Lizarrondo, Denis Vivien, Maxime Gauberti.
PUBLICATION ALERT : Nuclear Medicine Dept, University Hospital, Nantes - OncoTarget 2018
Comparison of Immuno-PET of CD138 and PET imaging with 64CuCl2 and 18F-FDG in a preclinical syngeneic model of multiple myeloma
In this report, the research team from University Hospital Nantes used the PhotonIMAGER RT to validate 64Cu-labeled anti-CD138 murine antibody PET localization Data in a multiple myeloma syngeneic mouse model.
Clément Bailly, Sébastien Gouard, Marie Lacombe, Patricia Remaud-Le Saëc, Benjamin Chalopin, Mickaël Bourgeois, Nicolas Chouin, Raphaël Tripier, Zakaria Halime, Ferid Haddad, Alain Faivre-Chauvet, Françoise Kraeber-Bodéré, Michel Chérel, and Caroline Bodet-Milin.
PUBLICATION ALERT : Inserm U1026, Bordeaux - Nature Scientific Reports - 2017
In situ printing of mesenchymal stromal cells, by laser-assisted bioprinting, for in vivo bone regeneration applications
In this report, researchers from Bordeaux university used the PhotonIMAGERTM RT to assess proliferation of multipotent bone marrow stromal precursor cells implanted in situ by laser assisted bioprinting (LAB) in a calvaria defect mouse model.
Virginie Keriquel, Hugo Oliveira, Murielle Rémy, Sophia Ziane, Samantha Delmond, Benoit Rousseau, Sylvie Rey, Sylvain Catros, Joelle Amédée, Fabien Guillemot & Jean-Christophe Fricain.
PUBLICATION ALERT : ETH Zurich - Psychopharmacology - 2017
The role of beta-arrestin2 in shaping fMRI BOLD responses to dopaminergic stimulation
In this report the authors used the digital autoradigraphy BetaIMAGER TRacer system to validate binding of tritiated ligands for for D1R, D2/3R, dopamine transporter (DAT) and vesdicular monoamine transporter-2 (VMAT2) in Wild-Type and beta-arrestin2 K/O mice before functional analysis by fMRI.
Kristoffer Sahlholm, Giovanna D. Ielacqua, Jinbin Xu, Lynne A. Jones, Felix Schlege, Robert H. Mach, Markus Rudin and Aileen Schroeter
PUBLICATION ALERT : INSERM - Nature communications - 2017
PUBLICATION ALERT : VUB / UZB - Mol Imaging Biol 2017
Improved Debulking of Peritoneal Tumor Implants by Near-Infrared Fluorescent Nanobody Image Guidance in an Experimental Mouse Model.
In this report the scientific teams from UVB and UZ Brussels used the PhotonIMAGER Optima to validate surgical efficiency of a debulking technique by fluorescence guided surgery using a NIR-labeled nanobody against HER2-positive tumors.
PUBLICATION ALERT: BARC - News Letter 2017
Potential of Luminescence Based Molecular Animal Imaging in Research Areas Pertaining to Cancer Biology and Therapy
PUBLICATION ALERT: Pharos University - Journal of Controlled Release
Hepatic stellate cell-targeted imatinib nanomedicine versus conventional imatinib: A novel strategy with potent efficacy in experimental liver fibrosis
PUBLICATION ALERT: Cardiff University - Molecular Biosciences Research Division . BIOTECHNOLOGY AND BIOENGINEERING.
ΔFlucs: Brighter Photinus pyralis firefly luciferases identified by surveying consecutive single amino acid deletion mutations in a thermostable variant
Publication Alert : CMIRO, Brussels /CMMI, Gosselies, Belgium - STEM CELLS AND DEVELOPMENT
Long-term In Vivo Monitoring of Adult-Derived Human Liver Stem/Progenitor Cells by Bioluminescence Imaging, Positron Emission Tomography, and Contrast-Enhanced Computed Tomography
Publication Alert : CEA - Cyceron - Caen - PLOSOne
[18F]Fludarabine-PET in a murine model of multiple myeloma
Publication Alert : Keele University - Acta Biomaterialia
Defining a turnover index for
the correlation of biomaterial degradation and cell basedextracellular matrix synthesis
using fluorescent tagging techniques
Defining a turnover index for the correlation of biomaterial degradation and cell basedextracellular matrix synthesis using fluorescent tagging techniques
New poster of Sanofi Pasteur for AFSTAL congress in Nantes