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Biospace Lab has also developed a tool to estimate mouse anatomy without X-Ray projections.

The Atlas co-registration tool is complementary with the 3D Module

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STEREOCT MODULE (Discontinued for redevelopment)
Approximation of 3D organ anatomy using only two 2D X-Ray projections

There’s an increasing need in preclinical imaging to be able to image subject in 3 dimensions, to detect, localize and follow signals that offers functional biological information about the subject.For in vivo pre-clinical optical imaging, the animal’ssurface topography and internal anatomy need to be estimated for improving thequantitative accuracy of reconstructed images. The animal’s surface profile can be measured by recent optical systems, but it is non-trivial to obtain reliable information about the internal structure of the subject in which the optical signal goes propagates.

Normally, if one researcher wants to co-register a fully tomographic modality with an optical imagingmodality, he should either physically combine the two systems or rely on the transfer of a speciallydesigned chamber that moves from one system to the other. The limitations ofthese two solutions are that the first one suffers from the complexity and high cost of the fully tomographic system and the second one from the challenge of data overlay and has the inherent risk of animal movements

To overcome this challenge, Biospace Lab developed a method to estimatethe 3D mouse anatomy more accurately from non-tomographic systems. With the use of a planar X-Ray coupled to the PhotonIMAGER optical imaging system, this technology allows the co-registration of a digital atlas using X-Ray projections. This way, we obtain the position of the optical signal source in 3D with fast acquisition and low dose radiation. Learn more about the operating principle of the StereoCT


The StereoCT Module is a smart way to easily add anatomical context
to your optical imaging studies

Download our article about the StereoCT Imaging and the Atlas Co-registration Tool.

Courtesy of B. Rousseau,
Victor Segalen Bordeaux II University, France

Key benefits of the StereoCT Module




· Provides3D anatomical references for better localization of optical signals in 3D-estimation of organ anatomy with no need for tomographic acquisitions

· Theatlas’ optical density information for each organ can be integrated to improvethe 3D signal reconstruction and quantification.

· Co-registers3D signal information from the PhotonIMAGER system with CT data stored in theAtlas Possible segmentation of the 3D signal with the anatomical information,provides automatic quantification of signal for each organ

· Fast and user friendly processing

· Low dose (<500 µGy)

· Fast (10-15 second acquisition; only seconds for reconstruction)

· 2 mice can be reconstructed at the same time




Vertical PixelResolution: 0.18mm/pixel

HorizontalPixel Resolution: 0.05mm/pixel

FOV in 3DImaging: 185x65mm (2 mice)

Dose: 30 to400 µSv

AcquisitionTime: 15s

ReconstructionTime: ~3min



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