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Biospace Lab’s digital autoradiography systems presents significant interests to complement in vivo acquisitions with

Indeed, autoradiography acquisitions only require the preparation of tissue
sections since the imagers will detect
the exact same labelling which have been used for the SPECT or PET acquisition.

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The high resolution digital autoradiography solution

The BetaIMAGER™ DFINE system is the system of choice for applications involving smaller tissue sections and where the best possible spatial resolution is required. Four samples, up to 24 x 32mm each in size can be loaded onto the automated stage for sequential image acquisition. Spatial resolution as high as 10μm can be achieved with Tritium. The DFINE is the perfect ex-vivo complement to PET and SPECT molecular imaging


The BetaIMAGER DFINE is 50 times faster than film with tritium labeled samples, allows precise quantitation, and boasts a 10μm resolution for tritiated samples unsurpassed by any other non film technique. No complex techniques or procedures to learn.

Key Benefits

- Fast and easy to operate.
- Real-time display avoids the risk of undervor over-exposure.
- White light imaging allows for the visualizationvof the sample.
- Non-destructive probe: slices are not damagedvor destroyed during the measurement.
- Exclusive patented dual label capabilityvsimultaneously detects detects and filters two or more isotopes.
- Precise quantitation

Ex vivo imaging of 11C retention in 22 months old female tg/tg APP/PS1 animals following bolus injection of a 11C/3H coctail. Yellow scale bars: 100µm.
Yousefi et al, 2010



Receptor Binding Assay

Caracterization of Serotonin receptors on a rat brain section, with 125I labelled serotonin-O-carboxyméthyl- glycile. The image shows an heterogeneous distribution with regions rich in 5-HT 1B and 5- HT 1D binding sites. The absence of saturation allows to distinguish all structures in the section.
Courtesy Louis Ségu, CNRS URA 339, Bordeaux, France

ISH of a 20 days mouse embryo using a 35S labelled probe specific to actin mRNA. Overnight acquisition (a week+ with film). Spaces between fingers is 50 μm. Courtesy IPN, Orsay, France.

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