Biospace Lab News
First In Vivo SPECT Imaging of Mouse Femorotibial Cartilage Using 99mTc-NTP 15-5
December, 2008
The Gamma Imager at the forefront of preclinical research on cartilage:
the team of Nicole Moins characterized a SPECT radiotracer specific to articular joints.
The modularity of the Gamma Imager made possible the use of planar and SPECT modes for both dynamic and static acquisitions.
Such results may offer a unique opportunity to achieve a greater understanding of cartilage physiology in health and disease.
Article avalaible on line.
Glowing, conscious, and free: New bioluminescence system performs whole-body imaging of moving rodents
November 20th, 2008
Analytical Chemistry published an article on the experiments performed
in the frame of the collaboration of the team of Pr. Tavitian (CEA Orsay) and Biospace Lab with the In Actio system.
This short article is freely
avalaible on line.
New device for real-time bioluminescence imaging in moving rodents: description of the In Actio design
October 3rd, 2008
New! A publication describing the technology of the In Actio module has been published in the Journal of Biomedical Optics.
The article, which also includes the description of the validation experiments performed with bioluminescent mice, is freely
avalaible on line.
A new European Network: ENCITE
June 20th-21st, 2008, Munich
Biospace Lab is participating to the creation of the European Network for Cell Imaging and Tracking Expertise (ENCITE),
supported by the European Commission's 7th Framework Programme (FP7), and co-ordinated by the EIBIR (European Institute for Biomedical Imaging Research).
Biospace Lab will be present at the Kick off meeting, held this week end in Munich.
Kinetics measurements with the beta microprobe in mice
June 18th, 2008, Paris
New! Major publication on Biospace Lab betamicroprobe. The team of Philippe Lanièce (UMR8165 CNRS-University Paris 7 and Paris 11) describes its work
for in vivo kinetics measurements of the binding of 18F-MPPF in mouse hippocampus.
Desbrée A, Verdurand M, Godart J, Dubois A, Mastrippolito R, Pain F, Pinot L, Delzescaux T, Gurden H, Zimmer L, Lanièce P: The Potential of a Radiosensitive Intracerebral Probe to Monitor 18F-MPPF Binding in Mouse Hippocampus In Vivo. J Nucl Med 2008 Jun 13 (2008).
List of all the betamicroprobe publications
Desbrée A, Verdurand M, Godart J, Dubois A, Mastrippolito R, Pain F, Pinot L, Delzescaux T, Gurden H, Zimmer L, Lanièce P: The Potential of a Radiosensitive Intracerebral Probe to Monitor 18F-MPPF Binding in Mouse Hippocampus In Vivo. J Nucl Med 2008 Jun 13 (2008).
List of all the betamicroprobe publications
A new molecule with potential anti-cancer effects
June 2008
A potentially anti-cancerous molecule, named HB19, was characterized and studied for its effect on
tumor growth and angiogenesis in vitro and in vivo. The Beta Imager was used to determine the biodistribution
of the molecule after systemic administration in rats. Whole body autoradiography of the rats showed a fast clearance from the blood to
tissues expressing significant levels of surface nucleotin, a cell surface protein involved in various processes like
cell proliferation, differentiation and angiogenesis.
The article from PLoS ONE:
Destouches D, El Khoury D, Hamma-Kourbali Y, Krust B, Albanese P, Katsoris P, Guichard G, Briand JP, Courty J, Hovanessian A: Suppression of Tumor Growth and Angiogenesis by a Specific Antagonist of the Cell-Surface Expressed Nucleolin PLoS ONE, 3(6): e2518 (2008)
The article published in the French newspaper Le Monde (French):
Une équipe francaise découvre une molécule potentiellement anticancéreuse
List of all the Beta Imager publications
The article from PLoS ONE:
Destouches D, El Khoury D, Hamma-Kourbali Y, Krust B, Albanese P, Katsoris P, Guichard G, Briand JP, Courty J, Hovanessian A: Suppression of Tumor Growth and Angiogenesis by a Specific Antagonist of the Cell-Surface Expressed Nucleolin PLoS ONE, 3(6): e2518 (2008)
The article published in the French newspaper Le Monde (French):
Une équipe francaise découvre une molécule potentiellement anticancéreuse
List of all the Beta Imager publications