Photon Imager
Oncology
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Abstract
Background: Many areas of research, including
gene and pharmacological therapeutics, would benefit from
longitudinal in vivo monitoring methodologies. To investigate
the feasibility of one such methodology, we developed a
murine mammary cancer model amenable to sequential
bioluminescent imaging of tumor growth and metastasis in
living animals. Materials and Methods: Metastatic mouse
mammary carcinoma BJMC3879 cells were transfected to
stably express firefly luciferase and inoculated into
immunocompetent female BALB/c mice. Results: Sequential
analysis using bioluminescent imaging showed increasing
photon counts correlated to expanding mammary tumor
volumes; in addition, strong signals from axillary,
mandibular, femoral, thoracic and abdominal regions in mice
were histopathologically determined to be due to metastases,
the majority of which occurred in lymph nodes and lungs.
Conclusion: The bioluminescent mouse mammary cancer
model we established provides a method for quantifiable
longitudinal in vivo imaging that can be used in gene and
pharmacological therapy applications.
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Molecular Imaging
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Neurosciences
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Infectious Diseases
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Cardiovascular Research
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Tissue Engineering
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Gastroenterology
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Drug discovery
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Gene Therapy
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Workshops and symposiums
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Abstract
Optical imaging is an efficient mean to measure biological signal.
However, it can suffer from low spatial and temporal resolution while animal deformable displacements could also
degrade significantly the localization of the measurements. In this paper, we propose a novel approach to perform
fusion of cinematic flow and optical imaging towards enhancement of the biological signal. To this end, fusion is
reformulated as a population (all vs. all) registration problem where the two (being spatially aligned) signals are
registered in time using the same deformation field. Implicit silhouette and landmark matching are considered for
the cinematic images and are combined with global statistical congealing-type measurements of the optical one.
The problem is reformulated using a discrete MRF, where optical imaging costs are expressed in singleton (global)
potentials, while smoothness constraints as well as cinematic measurements through pair-wise potentials.
Promising experimental results demonstrate the potentials of our approach
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Press articles and blogs
Calcium imaging is a technique that is definitely coming to age, and fancier and fancier genetically encoded indicators are constantly being developed [...]. The approach recently described in PlOS One by Rogers and colleagues is completely non invasive. They generated a transgenic mouse line expressing the calcium sensitive protein GFP-aequorin in an inducible manner through the use of a... Read more