Beta Microprobe

Radioactivity kinetic curves measured by b microprobe in hippocampus and cerebellum of anesthetized mice after 18F-MPPF injection.
From Desbrée A, Verdurand M, Godart J, Dubois A, Mastrippolito R, Pain F, Pinot L, Delzescaux T, Gurden H, Zimmer L, Lanièce P: The Potential of a Radiosensitive Intracerebral Probe to Monitor ¹⁸F-MPPF Binding in Mouse Hippocampus In Vivo. J Nucl Med 2008 Jun 13 (2008).

• Desbrée A, Verdurand M, Godart J, Dubois A, Mastrippolito R, Pain F, Pinot L, Delzescaux T, Gurden H, Zimmer L, Lanièce P: The Potential of a Radiosensitive Intracerebral Probe to Monitor ¹⁸F-MPPF Binding in Mouse Hippocampus In Vivo. J Nucl Med 2008 Jun 13 (2008).
• Millet P, Moulin M, Bartoli A, Del Guerra A, Ginovart N, Lemoucheux L, Buono S, Fagret D, Charnay Y, Ibañez V: In vivo quantification of 5-HT(1A)-[(18)F]MPPF interactions in rats using the YAP-(S)PET scanner and a beta-microprobe. Neuroimage 2008 Mar 14 (2008).
• Desbrée A, Rbah L, Langlois JB, Grenier D, Mastrippolito R, Pain F, Pinot L, Lanière P, Zimmer L, Gurden H. Simultaneous in vivo magnetic resonance imaging and radioactive measurements with the Beta-Microprobe. Eur J Nucl Med Mol Imaging 34:1868 1872 (2007).
• Moulin-Sallanon M, Millet P, Rousset C, Zimmer L, Debilly G, Petit JM, Cespuglio R, Magistretti P, Ibáñez V. Chloramphenicol decreases brain glucose utilization and modifies the sleep-wake cycle architecture in rats. J Neurochem 93(6):1623-32. (2005).
• Desbrée A, Pain F, Gurden H, Zimmer L, Pinot L, Lanièce P, Mastrippolito R. Combining the radiosensitive Beta MicroProbe to nuclear magnetic resonance: theoretical approach for in vivo studies in small animals. J Neurosci Methods 140(1-2):47-52. (2004).
• Zimmer L, Riad M, Rbah L, Belkacem-Kahlouli A, Le Bars D, Renaud B, Descarries L. Toward brain imaging of serotonin 5-HT1A autoreceptor internalization. Neuroimage 22(3):1421-6. (2004).
• Riad M, Zimmer L, Rbah L, Watkins KC, Hamon M, Descarries L. Acute treatment with the antidepressant fluoxetine internalizes 5-HT1A autoreceptors and reduces the in vivo binding of the PET radioligand [18F]MPPF in the nucleus raphe dorsalis of rat. J Neurosci 2004 Jun 9;24(23):5420-6.(2004).
• Ginovart N, Sun W, Wilson AA, Houle S, Kapur S. Quantitative validation of an intracerebral beta-sensitive microprobe system to determine in vivo drug-induced receptor occupancy using [11C]raclopride in rats. Synapse 52(2):89-99 (2004).
• Millet P, Sallanon MM, Petit JM, Charnay Y, Vallet P, Morel C, Cespuglio R, Magistretti PJ, Ibáñez V. In vivo measurement of glucose utilization in rats using a beta-microprobe: direct comparison with autoradiography. J Cereb Blood Flow Metab 24(9):1015-24. (2004).
• Pain F, Lanièce P, Mastrippolito R, Gervais P, Hantraye P, Besret L. Arterial input function measurement without blood sampling using a beta-microprobe in rats. J Nucl Med 45(9):1577-82. (2004). (link).
• Zimmer L, Rbah L, Giacomelli F, Le Bars D, Renaud B. A reduced extracellular serotonin level increases the 5-HT1A PET ligand 18F-MPPF binding in the rat hippocampus. J Nucl Med 44(9):1495-501. (2003).
• Zimmer L, Fournet G, Benoît J, Guillaumet G, Le Bars D.
  Carbon-11 labelling of 8[[3-[4-(2-[(11)C]methoxyphenyl)piperazin-1-yl]-2-hydroxypropyl]oxy]thiochroman, a presynaptic 5-HT(1A) receptor agonist, and its in vivo evaluation in anaesthetised rat and in awake cat. Nucl Med Biol 30(5):541-6. (2003).
• Rbah L, Leviel V, Zimmer L. Displacement of the PET ligand 18F-MPPF by the electrically evoked serotonin release in the rat hippocampus. Synapse. 49(4):239-45 (2003).
• Zimmer L, Pain F, Mauger G, Plenevaux A, Le Bars D, Mastrippolito R, Pujol JF, Renaud B, Lanièce P. The potential of the beta-Microprobe, an intracerebral radiosensitive probe, to monitor the [(18)F]MPPF binding in the rat dorsal raphe nucleus. Eur J Nucl Med Mol Imaging 29(9):1237-47. (2002).
• Pain F, Besret L, Vaufrey F, Grégoire MC, Pinot L, Gervais P, Ploux L, Bloch G, Mastrippolito R, Lanièce P, Hantraye P. In vivo quantification of localized neuronal activation and inhibition in the rat brain using a dedicated high temporal-resolution beta +-sensitive microprobe. Proc Natl Acad Sci U S A 99(16):10807-12. (2002). (Link)
• Zimmer L, Hassoun W, Pain F, Bonnefoi F, Lanièce P, Mastrippolito R, Pinot L, Pujol JF, Leviel V. SIC, an intracerebral beta(+)-range-sensitive probe for radiopharmacology investigations in small laboratory animals: binding studies with (11)C-raclopride. J Nucl Med 43(2):227-33. (2002).
• Zimmer L, Mauger G, Le Bars D, Bonmarchand G, Luxen A, Pujol JF. Effect of endogenous serotonin on the binding of the 5-hT1A PET ligand 18F-MPPF in the rat hippocampus: kinetic beta measurements combined with microdialysis. J Neurochem Jan;80(2):278-86. (2002).